Conference booklet in PDF format.

Monday 10th July 2023

9:30-9:55		Registration and coffee
9:55-10:00		Welcome
10:00-12:00	Chair: Martin Malý	Session 1
	Max Crispin	Opening presentation	Southampton
	Aaron Wall	Cross-recognition of bacterial and preproinsulin peptides by HLA A*24:02-restricted T-cell receptors in type 1 diabetes	Cardiff
	Catherine Tooke	Structural Investigations into Antibiotic Hydrolysis by the KPC-2 β-Lactamase	Bristol
	Dylan Ivory	Allosteric activation and inhibition of glycogen phosphorylase share common transient structural features	Exeter
	Matilda Clark	Biophysics to Bioreactors: Using Small Scale Experiments to Predict Enzyme Activity on a Large Scale	Portsmouth
12:00-13:45		Lunch and posters
13:45-15:50	Chair: Abigail Sudol	Session 2
	Matthew McLaren	In situ structure of a dimeric hibernating ribosome from a eukaryotic intracellular pathogen	Exeter
	Mohinder Pal	Cryo-EM structure of the R2TP chaperone and its role in macromolecular assembly	Sussex
	Emma Buzzard	Cryo-ET for investigating the role of respiratory chain organisation in health and disease	Exeter
	Mark Young	CryoEM structure and Alphafold modelling of slipper limpet hemocyanin	Cardiff
	Anil Kumar Jamithireddy	Exploring the catalytic core of yeast DNA-polymerase ε	Exeter
	Hassan Akram-Sheikh	New and Exciting Updates from Molecular Dimensions	Molecular Dimensions
15:50-16:30		Coffee and posters
16:30-18:15	Chair: Charlotte Cordery	Session 3
	Sam Horrell	Time-resolved Serial Crystallography at I24	DLS
	Chris Orr	Lasers, Phasing and Ion Taming: Long Wavelength MX at Beamline I23	DLS
	Anastasya Shilova	Sample delivery techniques to perform time-resolved serial crystallography at the XFEL Hub of Diamond Light Source	DLS
	Pedro Nunes	The High-energy Electron Xtallography Instrument: a tool for macromolecular structure determination	DLS
	Ivo Tews	CCP4 Overview	Southampton
19:00-23:00		Conference dinner – Dancing Man Brewery

Tuesday 11th July 2023

9:30-11:00	Chair: Isabel Elliot	Session 4
	Rosie Mundy	High Resolution Structure of HAdV-D10 Determined by Cryo-Electron Microscopy	Cardiff
	Becky Conners	Cryo-electron microscopy of the f1 filamentous phage reveals insights into viral infection and assembly	Exeter
	Michael Beer	Understanding the breakdown of enmetazobactam by the extended spectrum beta-lactamase GES-1	Bristol
	Kyle Gregory	Serendipity in crystallography	Bath
11:00-12:00		Coffee and posters
11:15-12:15		Computer workshops: – CCP-EM (Tom Burnley) – SAXS (Robert Rambo) – Paired refinement with PAIREF in CCP4 and crystallographic pubquiz (Martin Malý)
12:15-13:00		Lunch posters
13:00-14:30	Chair: Jack Stubbs	Session 5
	Patrick Shaw-Stewart	Sample preparation for routine and advanced structural biology, including serial data collection, microED, and cryoEM	Douglas Instruments
	Brooke Wain	Enzymatic Degradation of Crystalline Polyethylene Terephthalate (PET): Discovery, Engineering, and Structural Characterization of Novel Plastic-Degrading Enzymes	Portsmouth
	Bruce MacLachlan	Understanding the HLA class-II peptide presentation platform and its role in anti-SARS-CoV-2 T cell memory	Cardiff
	Jemma Roberts	Orthogonal Spectroscopy: Systems for the analysis of protein stability and structural changes	Applied Photophysics
14:30-15:15		Coffee and posters
15:15-17:15	Chair: Ivo Tews	Session 6
(15:15-15:40)	Simon Coles	Electron Diffraction at the National Crystallography Centre	Southampton
(15:40-16:05)	Tarik Drevon	Software development for ED in macromolecular crystallography	STFC
(16:05-16:30)	Nic Harmer	Advances in the use of microED and serial crystallography methods, an enzyme user case	Exeter
16:30-17:00	Phil Williamson	How does a “neuroinflammatory environment” influence the onset and progression of neurodegenerative disease	Southampton
17:00-17:15		Prizes and awards – kindly provided by Douglas Instruments
17:15		Depart

The programme is subject to change.